Sustained Disease Remission Increased by Adding Tocilizumab to Glucocorticoid Therapy in Patients with Giant-Cell Arteritis
Adding tocilizumab to tapered glucocorticoid therapy in patients with giant-cell arteritis (GCA) led to higher rates of sustained remission at 52 weeks than placebo plus tapered glucocorticoid therapy, according to the results of the phase 3, randomized, double-blind, 52-week, placebo-controlled GiACTA (GCA Actemra) trial.
One of the earliest observations of giant-cell arteritis (GCA) occurred in the 10th century when oculist ‘Alī ibn ‘Īsā al-Kahhal noted an association between inflamation of the temporal artery and blindness in his book, Tadhkirat.1 GCA is categorized as a large-vessel vasculitis targeting large- and medium-sized blood vessels, and the most feared complication associated with the disease is visual loss from cranial arteritis.
Treatment with abatacept plus a prednisone taper significantly reduced the rate of relapse and improved duration of remission compared with placebo in patients with giant cell arteritis (GCA) who achieved remission with abatacept plus prednisone.
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