Paracetamol (acetaminophen in the United States) appears to have more cardiovascular, gastrointestinal (GI), and renal toxicity, as well as increased risk of mortality, than has been previously assumed, especially at high doses, according to a systematic review of the literature published online.
Exposure to biologics around the time of conception does not appear to have negative effects on neonates, according to data from the German biologics RABBIT (Rheumatoid Arthritis Observation of Biologic Therapy) registry.
Fatigue is a frequent problem for people with rheumatoid arthritis (RA), and contributes to disease-related disability.
Although patients with rheumatoid arthritis (RA) undergo radiological evaluations, the actual use of radiological imaging in RA has not been adequately reported. A population-based study evaluated the use of radiological procedures in patients with RA compared with patients without RA.
Hydroxychloroquine should not be routinely given to patients with mild to moderate pain associated with osteoarthritis (OA) of the hand, according to the results of a randomized, double-blind, placebo-controlled, multicenter study.
Two conditions characterized by inflammation are linked, according to researchers: periodontal disease and rheumatoid arthritis (RA). In fact, it is possible that periodontal disease may trigger the onset of RA.
Higher body mass index (BMI) in patients with rheumatoid arthritis (RA) is linked to a poorer response to a second-line biologic drug after failure of first-line treatment with a tumor necrosis factor-alpha (TNF-alpha) inhibitor, according to a study published online in Joint Bone Spine.
Pregabalin (Lyrica Capsules CV; Pfizer) did not improve pain associated with fibromyalgia in adolescents aged 12 to 17 years, according to results of a phase 4 double-blind, placebo-controlled, Pfizer-sponsored, postmarketing study reported recently. Pregabalin capsules were not significantly better than placebo in improving mean pain score.
In the first study of the link between ankylosing spondylitis (AS) and epigenetic factors, investigators found an association between smoking, methylation status, and radiographic disease progression.
Triple therapy with conventional disease-modifying antirheumatic drugs (DMARDs) can achieve sustained remission in approximately 1 in 4 patients with early rheumatoid arthritis (RA).

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