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Renal Impairment

Renal insufficiency, defined by abnormal creatinine clearance, is present in almost 50% of multiple myeloma (MM) patients at presentation and contributes to significant early mortality.1 Over time, with relapsing disease, advancing age, and associated comorbidities, the incidence of this complication becomes even higher.2 Renal disease in MM commonly results from tubular disease with proximal and distal tubular dysfunction and myeloma cast nephropathy with consequent renal failure.3 Glomerulopathy from amyloid deposition, variants of light- and heavy-chain d

Multiple myeloma (MM) is a progressive malignancy of plasma cells in the bone marrow, associated with an increased level of monoclonal protein (M-protein) in the blood and urine.1 The increase in M-protein is directly linked to the development of renal insufficiency due to the precipitation of light chains in the renal tubes.2 This complication can adversely affect patient outcomes, as well as contribute to the cumulative costs of treatment through the increased need for supportive care and dialysis.


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  • Rheumatology Practice Management
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  • American Health & Drug Benefits
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  • Value-Based Care in Myeloma
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