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Adverse Events Watch

Patients with rheumatoid arthritis (RA) taking tocilizumab have a higher rate of lower intestinal perforations (LIPs) compared with patients taking conventional synthetic and other biologic disease-modifying antirheumatic drugs (DMARDs), according to results of a recent, comprehensive, registry-based study by Anja Strangfeld, MD, Department of Epidemiology, German Rheumatism Research Centre, Berlin, and colleagues.
Although patients with rheumatoid arthritis (RA) may be at an increased risk for ischemic stroke, researchers in a recent study have concluded that use of tumor necrosis factor inhibitors (TNFis) does not appear to influence the risk of ischemic stroke in this patient population.

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